Resumo A pesquisa no campo da administração pública encontra-se permanentemente desafiada a refletir sobre a complexa relação que envolve a administração e democracia. O retorno ao cenário nacional e internacional de forças políticas situadas no campo da extrema direita, que recorrem às regras do jogo democrático como ferramentas contra a clássica democracia liberal, coloca desafios teórico-epistemológicos adicionais ao campo. Quais os desafios e perspectivas da produção do saber no campo da administração, particularmente no que diz respeito à articulação entre modelos de gestão e democracia, considerando projetos de sociedade e modelos de desenvolvimento? Esse debate requer a mobilização de conhecimento crítico, o redesenho de objetos de estudo, do significado da participação, o aprofundamento do caráter interdisciplinar da pesquisa, além de explicitar a dimensão política da relação entre res publica e democracia. encontrase encontra se direita liberal teóricoepistemológicos teórico epistemológicos desenvolvimento crítico estudo participação

Abstract Public administration research is constantly challenged to reflect on the complex relations between administration and democracy. The national and international reemergence of far right political forces, which use democratic ground rules as tools against classic liberal democracy, poses additional theoretical and epistemological challenges to the field. Which knowledge production challenges and perspectives appear in the field of administration, especially regarding the articulation between management models and democracy, considering society projects and development models? Such a debate requires mobilizing critical knowledge, redesigning study subjects, reframing participation, deepening the interdisciplinary character of research, and clarifying the political dimensions of the relationship between res publica and democracy. democracy forces subjects participation

Abstract The University Pharmacy Program (FU), from the Federal University of Rio de Janeiro (UFRJ), was created based on the need to offer a curricular internship to students of the Undergraduate Course at the Faculty of Pharmacy. Currently, it is responsible for the care of about 200 patients/day, offering vacancies for curricular internships for students in the Pharmacy course, it has become a reference in the manipulation of many drugs neglected by the pharmaceutical industry and provides access to medicines for low-income users playing an important social function. Research is one of the pillars of FU-UFRJ and several master and doctoral students use the FU research laboratory in the development of dissertations and theses. As of 2002, the Pharmaceutical Care extension projects started to guarantee a rational and safe pharmacotherapy for the medicine users. From its beginning in 1982 until the current quarantine due to the COVID-19 pandemic, FU-UFRJ has been adapting to the new reality and continued to provide patient care services, maintaining its teaching, research, and extension activities. The FU plays a relevant social role in guaranteeing the low-income population access to special and neglected medicines, and to pharmaceutical and education services in health promotion.

Abstract Hydrogels are used for wound treatment, as they may contain one or more active components and protect the wound bed. Papain is one of the active substances that have been used with this purpose, alongside urea. In this paper, carboxypolymethylene hydrogels containing papain (2% and 10% concentrations) and urea (5% concentration) were produced. Physical-chemical stability was performed at 0, 7, 15 and 30 days at 2-8ºC, 25ºC and 40ºC, as well as the rheological aspects and proteolytic activity of papain by gel electrophoresis. Clinical efficacy of the formulations in patients with lower limb ulcers was also evaluated in a prospective, single-center, randomized, double-blind and comparative clinical trial. The results showed 7-day stability for the formulations under 25ºC, in addition to approximately 100% and 15% of protein activity for 10% and 2% papain hydrogel, respectively. The rheological profile was non-Newtonian for the 10% papain hydrogel tested. There were no significant differences regarding the mean time for healing of the lesions, although 10% papain presented a better approach to be used in all types of tissue present in the wound bed.

Abstract The objective of this paper was to develop and evaluate two semi-solid pharmaceutical forms containing 0.1% tacrolimus: cream (CRT01) and gel (GLT01). For the evaluation of physicochemical stability, at times 0, 30, 60 and 90 days, at 23°C and at 40°C, High Performance Liquid Chromatography coupled with a Diode Array Detector (HPLC-DAD) was employed. This method was developed and validated for tacrolimus quantification. The occlusivity test and skin permeation assay were also performed, using an animal model (Wistar rats), and the CRT01 and GLT01 were compared to the 0.1% tacrolimus ointment (PFU01) obtained from the University Pharmacy, Federal University of Rio de Janeiro, Brazil. CRT01 and GLT01 presented a homogeneous aspect and consistency adequate for topical products, along with sensory characteristics above PFU01. They also presented adequate physicochemical stability for 90 days and a lower occlusive effect than PFU01 (p<0.05). CRT01 showed greater affinity for the skin when compared to PFU01 and GLT01, with low systemic absorption. The CRT01 semi-solid formulation was considered the most adequate one to treat patients with atopic dermatitis or other dermatologic inflammatory diseases, promoting rational use of tacrolimus.

Abstract Oil-in-water photoprotective nanoemulsions (NEs) were developed using Babassu (BBS) lipophilic extract, nonionic surfactants, and low concentrations of organic sunscreens by ultrasonic processing. BBS extract was chosen due to its suitable physicochemical properties (acidity index, peroxide index, refraction index, and relative density) and predominance of saturated fatty acids, identified by gas chromatography-mass spectrometry (GC-MS), which promote biological activities and high oxidative stability. NEs were characterized by mean droplet size, morphology, polydispersity index (PdI), pH, and organoleptic properties, and the physical stability of the NEs was evaluated for 120 days at room temperature. The sun protection factor (SPF) was determined, and the photostability and in vitro cytotoxicity assays were performed for NEs. All NEs remained stable for 120 days, with a droplet size <150 nm and a monomodal distribution profile. The pH values were compatible with the skin’s pH. NE3 showed a spherical morphology, with a mean droplet size of 125.15 ± 0.16 nm and PdI of 0.145 ± 0.032. NE3 containing BBS extract and sunscreens presented an SPF of 35.5 ± 3.0, was photostable after 6 h of radiation and was non-cytotoxic to fibroblast cells. Thus, NE3 could be considered a promising formulation for developing synergic plant-extract sunscreen photoprotective products for the market.

Abstract The incorporation of antioxidants into sunscreens may provide additional skin photoprotection against the harmful photobiological effects of ultraviolet radiation. The present study evaluated the applicability of a screening approach to the assessment of the antioxidant and photoprotective properties of vitamin C, vitamin E, and coenzyme Q10 and then determined the performance of the most effective antioxidant in a sunscreen formulation. Antioxidant activity was assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, 2,2`-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and oxygen radical absorbance capacity (ORAC) assay, and the photoprotective potential was investigated by the yeast photoprotection assay. The antioxidant with the best effect was incorporated into sunscreen formulations which were evaluated for 120 days regarding their in vitro photoprotective parameters. Vitamin C showed high antioxidant capacity as well as a photoprotective potential against simulated solar irradiation applied for times longer than 1 h. Although the Sun Protection Factor, UVA/UVB ratio and critical wavelength did not differed significantly (p<0.05) between the formulation blank and the formulations containing 0.5% or 1% vitamin C, formulations with vitamin C kept their photostability for 6 months. Consequently, the proposed screening approach seems to be promising for the development of an antisolar photostable formulation containing vitamin C as an antioxidant.

Abstract The aim of this work was to develop an oral solution of captopril at 5 mg/mL preservative-free. Two formulations were prepared, one containing sweetener (formulation 1) and the other without this excipient (formulation 2). The results found of validation parameters from analytical method performed by HPLC for captopril were, linearity 0.9998, the limit of detection 15.71 µg/mL, the limit of quantification 47.60 µg/mL, repeatability 1.05%, intermediate precision 2.42%, accuracy intraday 101,53%, accuracy inter-day 99.85%. Moreover, the results found for captopril disulfide were, linearity 0.9999, limit of detection 0.65 µg/mL, limit of quantification 1.96 µg/mL, repeatability 2.28%, intermediate precision 1.51%, accuracy intraday 101.36%, accuracy inter-day 100.29%. The appearance of formulations was clear and colorless, pH measures were 3.12 and 3.04, dosage of captopril and captopril disulfide were 99.45% and 99.82%, 0.24% and 0.12% for formulation 1 and formulation 2, respectively. The stability study demonstrated that the concentration of captopril and captopril disulfide in the formulations was > 90% and below 3%, respectively. The in vivo palatability study in animals and humans showed that Formulation 1 containing the sweetener had better acceptance. Thus, the sweetener was able to improve the unpleasant taste of the formulation.

OBJECTIVES: Comprehensive care for people living with human immunodeficiency virus (HIV) (PLH) includes the promotion of healthier habits, including physical activity (PA). This study aimed to describe a multicomponent pragmatic trial protocol to assess the effect of PA in preventing body changes and metabolic disturbances, improving the quality of life of PLH starting antiretroviral therapy (ART) and present cohort characteristics. METHODS: PLH undergoing ART for ≤4 months were recruited for a randomized trial. The intervention comprised three cardiorespiratory and/or strength training sessions per week at the clinic or in public spaces for 6 months under on-site or remote supervision, and educational sessions. Participants’ PA levels, cardiorespiratory fitness, anthropometric measures, strength, flexibility, quality of life, and laboratory monitoring (blood glucose and lipids, CD4 counts) at baseline and post-intervention will be compared. The pragmatic design aims to enable the assessment of intervention effectiveness in real-life conditions. RESULTS: At baseline, our cohort of 38 recently diagnosed patients (mean time since HIV diagnosis and duration of ART were 3 and 2.58 months, respectively) were predominantly male, young, with high schooling and good immune status (median CD4 count=498 cells/mm3). Twenty-two (57.9%) patients reported a PA below the World Health Organization recommendations. We found baseline normal anthropometric measures and metabolic parameters: below-average trunk flexion and elbow extension strength, poor handgrip strength and flexibility, and high quality of life scores in all except the physical domain. CONCLUSIONS: Understanding how effective PA is in preventing body changes and metabolic disturbances, and in improving the quality of PLH starting ART may help establish guidelines to better incorporate PA in HIV care.

Resumo Este artigo teve por objetivo analisar a literatura do poeta Fuzzil, de modo a identificar em seus textos representações acerca de seus momentos identitários. Para tanto, analisamos trechos de suas três obras, “Um presente para o gueto” (2007), “Caturra” (2012) e “Céu de Agosto” (2013), bem como uma entrevista com o autor. Verificou-se que à medida que o poeta é interpelado pelas artimanhas poéticas e negras de recitais periféricos e de autores e versadores negros, é também convocado a explorar possibilidades para suas articulações enquanto escritor e versador antes apenas timidamente tangenciadas. Constata-se, assim, em Fuzzil, a transformação de realidades massacrantes em poesia, por meio de novos significados, como formas ativas de localizar-se como produtor de si, de localizar-se como sujeito e de subverter a posição de invisibilidade pública e política - e, por que não, poética? - socialmente imposta aos seus antecessores e a muitos pares de sua época.

Abstract This article aimed to analyze the literature of the poet Fuzzil, in order to identify in his texts representations that announce his identity moments. Therefore, we analyze excerpts of his three works “Um presente para o Gueto” (2007), “Caturra” (2010) and “Céu de Agosto” (2013) and an interview with the author. We verified that when the poet is asked by the poetic and Black wiles of peripherals recitals and Black authors and reciters, he is called to explore possibilities for his joints as a writer and reciter previously only timidly exploited. It appears, thus, to Fuzzil, the processing of punishing realities into poetry, through new meanings, as active ways to locate him as a producer of himself, to be located as a subject and subvert the public and policy invisibility position - and, why not, poetic? - socially imposed on its predecessors and on many pairs of his time.

The authors present a case of an ovarian ectopic pregnancy in a patient with an intrauterine copper device. Ovarian pregnancies are rare and account for three percent of ectopic pregnancies and the presence of an intrauterine device appears to influence its risk. The sonographic diagnosis of an ovarian pregnancy is difficult and, therefore, its diagnosis is only typically made during surgery and must be confirmed through histopathological analysis. As shown through our case, maximum conservative surgery of normal ovarian tissue can be attempted successfully.

At the hospital, the pharmacist is constantly challenged to prepare extemporaneous solutions from tablets, capsules or drug powder for patients unable to swallow, such as pediatric, elderly and patients that use nasoenteric and nasogastric tubes. The preparation of extemporaneous solutions from capsules, tablets and drug powder requires stability studies analysis. This article is a bibliographic review of preparation of extemporaneous oral liquid from solid oral dosage forms used in clinical practice. The selected articles contain all the information regarding manipulation techniques, pharmaceutical excipients, packaging, storage conditions and results of stability studies above 90% performed by HPLC analysis. In addition, a situational analysis of the strategies for the preparation of the extemporaneous solution was described to help the manipulator in the decision. The preparation of extemporaneous solution from solid oral dosage forms is based on information from official compendium or scientific literature, to ensure safe and effective manipulated medicine.

This work deals with development and evaluation of MFQ protective formulation, which contains two organic filters, namely: octyl-p-methoxycinnamate (OMC) and benzophenone-3 (BP-3); a photostabilizing agent called ethylhexylmethoxycrylene (EHMCR) and keratin particles. The MFQ formulation was evaluated in order to measure its pH, spin-spin lattice relaxation time (T2H), occlusivity factor, formulation efficacy, photostability and skin permeation, as well as keratin particle properties. Keratin particle size increased when incorporated to formulation, however, it did not affect pH. The MFQ formulation was found to be photostable and photoprotective, as evidenced by sunlight photostability test, sun protection factor (SPF), UVA/UVB ratio and critical wavelength. Interaction between keratin particles and active substances (OMC, BP-3 and EHMCR) was evidenced by T2H measurements. Evidences suggest that keratin reduces the permeation of both UV filters employed along this study, therefore, it can be stated that keratin has a promising potential for use in sunscreen formulations.

Abstract: Tapioca starch (TS) is produced from Cassaca roots and it is differentiated from other starches because it contains about 17–20% amylase and low amount of residual substances. Propranolol (POP) is a non-selective beta-adrenergic blocking agent and it is in the World Health Organization’s List of Essential Medicines. The aim of this work was to investigate the potential of TS in the development of POP tablets by means of direct compression. Its evaluation was performed by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) relaxometry, scanning electron microscopy (SEM), uniformity of weight, drug content, disintegration, friability, hardness, dissolution test and drug release kinetics. The TS granules were spherical with mean diameter of 10.09 ± 1.85 µm. The XRD, FTIR and NMR suggested physical interaction between TS and POP. The tablets presented average diameter of 1.1 ± 0.0 cm, 0.24 ± 0.02 cm thickness and average weight of 0.544 ± 0.003 g. The hardness of tablets was 10.98 ± 0.31 N and the percentage of friability was 25.74 ± 0.08%. POP was released after 45 min and the release kinetics properly fitted the Hixson-Crowell equation.

Resumo: O texto visa discutir os fatores dificultadores e facilitadores para a implementação da Lei nº 10.639/03, que coloca a necessidade de se trabalhar conteúdos de História e Cultura Afro-brasileiras no ensino. Passada mais de uma década de sua promulgação, nota-se que sua aplicação é atravessada por uma série de controvérsias. Neste contexto, propõe-se pensar currículo e proposta político-pedagógica entendendo que excelência educacional é uma questão que não deve ser descolada da noção de equidade. Para que seja efetivado um ensino pluriversal deve-se antes problematizar as artimanhas do epistemicídio na efetivação ou contestação de conteúdos no processo de ensino-aprendizagem.

Abstract: The text aims to discuss factors that complicate or facilitate the implementation of Law 10.639/03, which places the need to work contents of Afro-Brazilian History and Culture in education. It has passed more than a decade of its promulgation, but we note that its application is crossed by a series of controversies. Therefore, it is proposed to think curriculum and political-pedagogical proposal by understanding that educational excellence is a matter that should not be detached from the notion of equity. In order to release one pluriversal education, we shall discuss before the wiles of epistemicide in the execution or defense of contents in the teaching-learning process.

Objetivos: Avaliar a perceção que os profissionais de saúde dos cuidados de saúde primários têm sobre a formação recebida em saúde do adolescente e identificar as limitações sentidas e as necessidades de formação adicional. Tipo de estudo: Estudo observacional, transversal e descritivo. Local: Região Centro. População: Médicos e enfermeiros de família da região Centro. Métodos: Os médicos e enfermeiros de família inscritos numa formação de saúde do adolescente foram convidados a responder a um inquérito em que se solicitava a avaliação da sua formação pré e pós-graduada em saúde do adolescente, a necessidade de receber formação adicional e as limitações. Resultados: A maioria dos participantes considerou que a sua formação pré-graduada era insuficiente (médicos: 97%; enfermeiros: 77,2%) e que não se sentia apto para lidar com adolescentes após a licenciatura (médicos: 93,9%; enfermeiros: 87,7%). A maioria dos médicos de família também considerou insuficiente a formação recebida durante o internato (77,5%), não se sentindo aptos a lidar com adolescentes no final do mesmo (68,4%), tendo ainda considerado insuficiente a formação frequentada após o internato (73,0%). Os participantes consideraram ter necessidade de receber formação adicional em saúde do adolescente, apontando áreas com maiores necessidades formativas: as queixas psicossomáticas (82,2%), os problemas familiares (72,9%), a entrevista ao adolescente (69,5%), o consumo de substâncias (62,6%) e os problemas escolares e de comportamento (62,3%). Conclusões: Os médicos e enfermeiros de família inquiridos referiram sentir importantes lacunas formativas em saúde do adolescente na sua formação pré e pós-graduada, bem como a necessidade de obter mais formação nesta área.

Objectives: To assess the perceptions of primary care professionals on the training received in adolescent health, and to identify the perceived limitations and additional training needs. Study design: Observational, cross-sectional and descriptive study. Setting: Centre region. Population: Family physicians and nurses of the Centre region. Methods: The family physicians and nurses enrolled in an adolescent health training session were invited to answer a survey in which they were asked to evaluate their pre- and post-graduate training in adolescent health, the need to receive further training, and the limitations. Results: Most participants considered that their pre-graduate training was insufficient (physicians: 97%; nurses: 77.2%) and did not feel able to deal with adolescents after graduation (physicians: 93.9%; nurses: 87.7%). The majority of family physicians also considered that the training received during residency was insufficient (77.5%); they didn't feel able to deal with adolescents upon finishing residency (68.4%), and considered that the training received after residency was also insufficient (73.0%). Participants considered that they need additional training in adolescent health, pointing out areas with greater training needs: psychosomatic complaints (82.2%), family problems (72.9%), clinical interview (69.5%), substance use (62.6%), and school and behavioral problems (62.3%). Conclusions: The family physicians and nurses interviewed reported significant training gaps in adolescent health, both in their pre- and post-graduate training, as well as the need to obtain further training in this area.